Basic Analysis

Function & Application

Nattokinase (NK for short), also known as subtilisin, is a serine protease produced by Bacillus subtilisl natto during the fermentation of natto. It has the functions of dissolving thrombus, reducing blood viscosity, improving blood circulation, softening and increasing blood vessel elasticity.

 A significant function of nattokinase is to dissolve thrombus. Mimugu F et al. used the clot lysis analysis method to determine the fibrinolytic activity of nattokinase, and compared it with Plasmin, and found that the fibrinolytic activity of nattokinase was 4 times that of Plasmin; MiLsugu. F. When nattokinase was injected intravenously into a chemically induced thrombosis model, it was found that there was obvious thrombolysis, and it showed a higher fibrinolytic ability than plasmin and elastase. The above studies indicate that nattokinase exhibits strong fibrinolytic activity both in vitro and in vivo. Nattokinase can also activate plasminogen in the body, thereby increasing the amount of endogenous plasmin. in addition. After oral administration of nattokinase in healthy people, the following effects appear:

• Obviously shorten the dissolution time (ELT) of euglobulin;

• Increased fibrinolytic activity in plasma;

• The amount of t-PA in plasma has increased. Due to NK's safety, stability and good thrombolytic effect, it may be used as an oral agent for thrombosis treatment.