WS-12 (CAS 68489-09-8) is a versatile synthetic cooling compound rapidly emerging as a game-changer across food, cosmetics, and biomedical sectors. This odorless, food-grade powder delivers 1.5 times the cooling intensity of menthol with superior performance and broad applicability.
Chemical Profile
- IUPAC Name: N-(4-Methoxyphenyl)-p-menthane-3-carboxamide
- Molecular Formula: C18H27NO2
- Molecular Weight: 289.416 g/mol
- Purity: 99% minimum
- Melting Point: 179-183 degrees Celsius
Key Advantages
- 1.5x cooling intensity: Delivers prolonged chilling effect (10-20 minutes) compared to menthol
- Synergistic action: Enhances performance when combined with WS-23 or WS-3
- TRPM8 agonist: Activates cold-sensitive receptors, valuable for neuropathic pain research
- Odorless and tasteless: Does not interfere with product flavor profiles
Applications
Food and Beverage: Confectionery, gum, beverages, and dairy products benefit from WS-12’s long-lasting cooling without minty taste.
Cosmetics: Skin care, shampoo, shower gel, and oral care products use WS-12 for refreshing sensation.
Pharmaceutical: TRPM8 receptor research, neuropathic pain treatment development, topical analgesics.
E-liquid: WS-12 provides whole-mouth cooling that complements WS-23 (front) and WS-3 (throat) for multi-dimensional cooling blends.
Blending Recommendations
- WS-23 + WS-12 (2:1): Intense initial cool with extended duration for beverages
- WS-3 + WS-12 (1:1): Throat + whole mouth for confectionery
- WS-5 + WS-12 (1:2): Maximum long-lasting cooling for extreme products
Xi’an Taima supplies WS-12 with 99%+ purity, full COA and MSDS documentation. Free samples available. Contact us for wholesale pricing.